Colloidal silver blue guy12/19/2023 ![]() ![]() One of the main characteristics of silver is its oligodynamic effect, which is defined as the high microbicidal capacity of silver ions in water at a very low concentration (one part per million). This suspension of submicroscopic silver particles does not attack the bacteria directly, but causes a deactivation of enzymes responsible for their respiration, multiplication, and metabolism. It was reported that colloidal silver can significantly reduce the duration and severity of many bacterial infections such as septic wounds. In this context, colloidal silver gained renewed interest. Therefore, there is an urgent need to find new therapeutic approaches in order to achieve better success in the bacterial infection treatment. Currently, the appearance of MDR bacteria makes it impossible to find an effective drug to treat certain infectious diseases. represent an increasing worldwide problem. Infections caused by multidrug-resistant (MDR) Gram-negative and Gram-positive bacteria such as Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter, Staphylococcus spp., and Enterococcus spp. Altogether, these results suggest that CS could be an effective treatment for infections caused by MDR Gram-negative and Gram-positive bacteria. Furthermore, we found that CS significantly increased the ROS production in Gram-negative with respect to Gram-positive bacteria at 24 h of incubation. CS was bactericidal, during 24 h, at 1× and 2× MIC against Gram-negative bacteria, and at 2× MIC against Gram-positive bacteria, and it did not affect their membrane permeabilization. Membrane permeation and bacterial reactive oxygen species (ROS) production were determined in presence of CS. The minimal inhibitory concentration (MIC) of CS was determined for all strains by using microdilution assay, and time–kill curve assays of representative reference and MDR strains of these bacteria were performed. A total of 270 strains ( Acinetobacter baumannii ( n = 45), Pseudomonas aeruginosa ( n = 25), Escherichia coli ( n = 79), Klebsiella pneumoniae ( n = 58)], Staphylococcus aureus ( n = 34), Staphylococcus epidermidis ( n = 14), and Enterococcus species ( n = 15)) were used. Here, we aimed to evaluate the in vitro activity of colloidal silver (CS) against multidrug-resistant (MDR) Gram-negative and Gram-positive bacteria. ![]() Silver was used to treat bacterial infections since antiquity due to its known antimicrobial properties. Due to the emergence of antimicrobial resistance, new alternative therapies are needed. ![]()
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